REASON: The circulator is not turning on due to thermal switch reset. This occurs when the TCS pump is not primed properly.

PRE-REQUISITE: Service Engineer or person performing this service must have proper training in servicing the instrument. RESETTING THE THERMAL SAFETY SWITCH Step 1. Turn off the TCS and unplug from the AC outlet prior to resetting the thermal switch. Make sure that the TCS has had time to cool down prior to resetting the thermal safety switch. This can take up to 10 to 20 minutes. On the back of the TCS there is a small access hole where the thermal safety switch is located (As shown below). Using a non-metallic tool or the end of a pen or pencil, reset the thermal safety switch by depressing the button.

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You should feel or hear a click indicating that the switch has been reset. Once the thermal safety switch has been reset, make sure the TCS has been properly primed or the thermal safety switch will trip again. Please see Priming the TCS Pump steps below. Turn on the unit and enable the heater. Information about resetting the thermal safety switch can be found on page 3-14 in the 2100C Operation Manual.

Kontakt Player 4 Torrent Mac Software there. Information about priming the pump can be found on page 2-6 in the 2100C Operation Manual and on page 2-8 of the EVO 6300 Operation Manual. PRIMING THE TCS PUMP Step 1. Attach a 24 inches (61 cm) long x ½ inch (13mm) ID drain tubing to drain valve. Raise the drain tubing to vertical position as shown. Drain valve should be tilted up. Cover the end of the tubing with your thumb and open the drain valve.

Slowly lower the tubing while slowly opening the end of the tubing allowing water to fill up as much of the tubing. Once filled, close again the end of the tubing with your thumb and raise the tubing. Uncover the end of tubing to force water in to the pump inlet. Perform this step at least two to three times. Turn on the TCS circulator and observe that air has been purged from the pump indicating that the pump was primed correctly. If it does not, repeat step 2 and 3 until all the air is purged from the pump. When connecting a Distek dissolution system to the Evolution 4300 syringe-pump dissolution autosampler, you will need to connect an RS-485 cable between the two systems to allow for electronic control of the dissolution unit from the autosampler.

Depending on the type of dissolution system that is being utilized with the Evolution 4300 autosampler, the specific RS-485 cable needed will be different (the connecting ends are different). If you have our new symphony 7100 or Model 2500, you will need part number 2700-0162 (RS-485 Cable for 4300 Sampler to 7100 and 2500).

If you are using an Evolution 6100, Evolution 6300 or 2100C, you will need part number 2400-0004 (RS-485 Cable for 4300 Sampler to 2100C, 6100, and 6300). Model 2500 During a recent Model 2500 presentation we were asked the following: Question: “Besides the discontinuation of the 2100C, what additional justification would you recommend for us in replacing a 2100C with the new 2500?” Answer: Added Control and Compliance • The Audit Trail records the last 50 changes made to a method, should an investigation occur. • Three user access levels limit user abilities and permissions. • The 100 most recent test reports are saved, allowing them to be reviewed at a later date if necessary. Additional Time-Savings • The ability to store methods allows users to quickly select an entered method and run it without re-entering parameters. • TCS wake timer allows the bath to be pre-heated and ready for use prior to arrival of laboratory staff.

Ease of Use • Intuitive touch-screen interface simplifies entry of key parameters (RPM/Temperature/Time) from one screen. • Firmware updates can be easily emailed or downloaded from the internet to a USB Key eliminating the replacement of firmware chips. The intrinsic dissolution rate is defined as the dissolution rate of pure substances under the condition of constant surface area, agitation-stirring speed, pH and ionic-strength of the dissolution medium.

The knowledge of intrinsic dissolution rate is vital in screening new drug candidates as it can help optimize the physiological effectiveness of new dosage forms. Distek has improved the performance and reliability of the rotating cylinder or “wood apparatus” with the paddle over stationary disk intrinsic apparatus. This is available in two configurations; standard for use with 1L vessel and mini for use with 100/200 ml vessels. The Distek design avoids the formation of air bubbles on the surface of the product and eliminates the potential of product “slippage” as can be the case with the wood apparatus. The Distek standard and mini intrinsic apparatus consists of steel punch, die, and base plate (fig.